In anaphylaxis after IM antibiotic administration, which manifestation is expected first?

In anaphylaxis after IM antibiotic administration, which manifestation is expected first?

• A. Hives
• B. Wheezing
• C. Hypotension
• D. Nausea

Answer: (A)

When anaphylaxis starts, skin symptoms from histamine release tend to appear first. Hives and itching reflect immediate cutaneous involvement as blood vessels in the skin become permeable and fluids leak into the tissue. This early skin reaction is common and often precedes airway problems, so hives are the expected first manifestation after an IM antibiotic exposure. Breathing difficulties like wheezing come next as bronchoconstriction develops, and a drop in blood pressure follows from widespread vasodilation and fluid leakage. Nausea can occur but is not typically the earliest clue. Recognizing the very first skin signs helps you act quickly to treat the reaction and protect the airway and circulation.

When anaphylaxis starts, skin symptoms from histamine release tend to appear first. Hives and itching reflect immediate cutaneous involvement as blood vessels in the skin become permeable and fluids leak into the tissue. This early skin reaction is common and often precedes airway problems, so hives are the expected first manifestation after an IM antibiotic exposure. Breathing difficulties like wheezing come next as bronchoconstriction develops, and a drop in blood pressure follows from widespread vasodilation and fluid leakage. Nausea can occur but is not typically the earliest clue. Recognizing the very first skin signs helps you act quickly to treat the reaction and protect the airway and circulation.